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KMID : 1022820210120010001
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Journal of Multiple Sclerosis and Neuroimmunology
2021 Volume.12 No. 1 p.1 ~ p.5
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Steroid-Unresponsive Immune-Mediated Necrotizing Myopathy Successfully Treated with Rituximab
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Kim Jong-Su
Kim Seon-Deuk
Ju Woo-Hee
Park Soo-Hyun
Shin Je-Young
Sung Jung-Joon
Choi Seok-Jin
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Abstract
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Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies characterized by pathological findings including many necrotic muscle fibers and sparse infiltration of inflammatory cells. Although about 20% of patients with IMNM remain seronegative, most IMNMs are associated with anti-signal recognition particle or anti-3-hydroxy3-methylglutaryl-CoA reductase autoantibodies. Therapeutically, the mainstay of treatment of IMNM is corticosteroid, and intravenous immunoglobulin and rituximab have emerged as second-line therapy. Herein, we describe a rare case of steroid-resistant IMNM successfully treated with rituximab.
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KEYWORD
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Myositis, Steroids, Rituximab
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